LEWIS-ACID ASSISTED CYCLIZATION OF ARYLCYANOGUANIDINES TO 2,4-DIAMINOQUINAZOLINES

Authors
JONES ML KUYPER LF STYLES VL CADDELL JM
Citation
Ml. Jones et al., LEWIS-ACID ASSISTED CYCLIZATION OF ARYLCYANOGUANIDINES TO 2,4-DIAMINOQUINAZOLINES, Journal of heterocyclic chemistry, 31(6), 1994, pp. 1681-1683
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
31
Issue
6
Year of publication
1994
Pages
1681 - 1683
Database
ISI
SICI code
0022-152X(1994)31:6<1681:LACOAT>2.0.ZU;2-C
Abstract
The mild preparation of N-cyano-N'-(1-H-indol-5-yl)guanidine and its c yclization to 1,3-diamino-7H-pyrrolo[3,2-f]quinazoline is described. W hereas previously reported methods of cyclization employed high temper atures to effect ring closure, we found that certain Lewis acids, such as boron trifluoride etherate, induce cyclization at moderate tempera tures.