The mammalian spermatozoa are endowed with a unique cytoskeleton which
consists both of ubiquitous and specific proteins, some of them arisi
ng from a gene haploid transcription. In the head, a dense perinuclear
layer is made of basic proteins (calicin, cylicin, etc) associated wi
th calmodulin and actin remnants. In the flagellum, the axonemal micro
tubules are mainly composed of glutamylated tubulin isoforms; the peri
axonemal outer dense fibers and fibrous sheath are considered as relat
ed cytoskeletal structures on the basis of some common polypeptides.