This paper addresses several aspects of the applications of kinetic-ba
sed methods for single-component determinations of non-catalysts. One
goal is to review many of the different approaches to these kinetic-ba
sed determinations. A second goal is to organize many of these differe
nt approaches into a systematic classification scheme. A third goal is
to present mathematical descriptions that help to differentiate among
the different approaches. A fourth goal is to differentiate among imp
ortant features of the different approaches with emphasis on the rugge
dness of the different options. In this context, ruggedness is defined
as the ability of a method to resist changes in experimental variable
s. It is concluded that available options can be grouped into one or m
ore of four general categories in this regard, namely those with no ab
ility to resist changes in experimental variables, those that resist s
uch changes via temporal optimization, those that can be used in modes
that compensate for changing variables extrinsically and those that h
ave built-in (intrinsic) variable compensation. A fifth goal is to pla
ce the many different options to kinetic-based determinations into a s
omewhat broader and more consistent perspective than may have been don
e previously. In particular, an aim is to identify similarities among
measurement and data-processing options applied to transient (kinetic)
aspects of chemical, physico-chemical and physical processes.