Objective. To document the radiologic abnormalities in patients with s
ystemic onset juvenile rheumatoid arthritis (SOJRA) including abnormal
ities occurring early in the course of disease. Methods. A retrospecti
ve review of the charts and radiographs of 42 consecutive children wit
h SOJRA was carried out. Radiographs were reviewed by a single experie
nced radiologist with no knowledge of the clinical course of the patie
nts. Results. Soft tissue swelling and osteoporosis were the most comm
on radiologic abnormalities (34/42; 81%). Cartilage loss and/or bone e
rosions were also common, occurring in 50% of patients. Erosions occur
red within 2 years of disease onset in 11/36 (31%). Subchondral irregu
larity and sclerosis within 2 years of disease onset preceded erosions
in 11 patients with serial radiographs. Severe radiologic abnormaliti
es included joint ankylosis (8/42; 19%), subluxation (9/42; 21%), and
protrusio acetabuli (4/42; 10%). Joint ankylosis occurred most commonl
y between 3 and 5 years after disease onset and subluxation between 2
and 6 years. Conclusion. A subgroup of children with SOJRA develops ea
rly destructive radiologic changes whose severity is comparable to tho
se of children with rheumatoid factor positive polyarticular JRA. Earl
y subchondral changes may be predictive of subsequent erosive disease
in SOJRA and require prospective study using newer imaging techniques.