STUDIES ON PENAM SULFONES .3. SYNTHESIS AND BETA-LACTAMASE INHIBITORYACTIVITY OF SODIUM MINOMETHYL-2-ALPHA-METHYLPENAM-3-ALPHA-CARBOXYLATE1,1-DIOXIDE AND SODIUM -BETA-ACYL-2-ALPHA-METHYLPENAM-3-ALPHA-CARBOXYLATE 1,1-DIOXIDE

Authors
CZAJKOWSKI DP REDDY AVN SETTI EL PHILLIPS OA MICETICH RG KUNUGITA C MAITI SN
Citation
Dp. Czajkowski et al., STUDIES ON PENAM SULFONES .3. SYNTHESIS AND BETA-LACTAMASE INHIBITORYACTIVITY OF SODIUM MINOMETHYL-2-ALPHA-METHYLPENAM-3-ALPHA-CARBOXYLATE1,1-DIOXIDE AND SODIUM -BETA-ACYL-2-ALPHA-METHYLPENAM-3-ALPHA-CARBOXYLATE 1,1-DIOXIDE, Bioorganic & medicinal chemistry letters, 7(1), 1997, pp. 11-14
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
1
Year of publication
1997
Pages
11 - 14
Database
ISI
SICI code
0960-894X(1997)7:1<11:SOPS.S>2.0.ZU;2-G
Abstract
The synthesis and in vitro synergies of (6R)-6-(alpha-hydroxybenzyl)-2 beta-methoxyiminomethyl-2 alpha-methylpenam-3 alpha-carboxylate 1,1-d ioxide (4) and 2 beta-acyl-2 alpha-methylpenam-3 alpha-carboxylate 1,1 -dioxide (15) are described. Compound 15 showed good in vitro synergy in combination with piperacillin and ceftazidime against chromosomally mediated class I cephalosporinase producing organisms including TEM, SHV, and OXA-type enzymes producing microorganisms. Copyright (C) 1996 Elsevier Science Ltd