BLEOMYCIN MODEL COMPLEX BEARING A CARBAMOYL DERIVED SUBSTITUENT CAPABLE OF COORDINATION TO THE CHELATED METAL-ION AS A 6TH LIGAND

Authors
ARAI T SHINOZUKA K SAWAI H
Citation
T. Arai et al., BLEOMYCIN MODEL COMPLEX BEARING A CARBAMOYL DERIVED SUBSTITUENT CAPABLE OF COORDINATION TO THE CHELATED METAL-ION AS A 6TH LIGAND, Bioorganic & medicinal chemistry letters, 7(1), 1997, pp. 15-18
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
1
Year of publication
1997
Pages
15 - 18
Database
ISI
SICI code
0960-894X(1997)7:1<15:BMCBAC>2.0.ZU;2-P
Abstract
A new, simple bleomycin (BLM) model compound bearing a carbamoyl group mimicking BLM's sugar-tagged carbamoyl moiety was synthesized and the physicochemical properties of its divalent metal complexes were studi ed. The Fe complex of the model compound exhibited enhanced oxygen act ivating ability. Copyright (C) 1996 Elsevier Science Ltd