THE SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME KNOWN AND PUTATIVE METABOLITES OF THE ATYPICAL ANTIPSYCHOTIC AGENT OLANZAPINE (LY170053)

Authors
CALLIGARO DO FAIRHURST J HOTTEN TM MOORE NA TUPPER DE
Citation
Do. Calligaro et al., THE SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME KNOWN AND PUTATIVE METABOLITES OF THE ATYPICAL ANTIPSYCHOTIC AGENT OLANZAPINE (LY170053), Bioorganic & medicinal chemistry letters, 7(1), 1997, pp. 25-30
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
1
Year of publication
1997
Pages
25 - 30
Database
ISI
SICI code
0960-894X(1997)7:1<25:TSABOS>2.0.ZU;2-0
Abstract
4'-N-desmethyl olanzapine (2), olanzapine 4'-N-oxide (3) and 2-hydroxy methyl olanzapine (5), have been prepared and their pharmacology compa red to that of the parent compound olanzapine (1). The 4'-N-quaternary glucuronide (8) has also been prepared. Copyright (C) 1996 Elsevier S cience Ltd