A NEW SERIES OF SELECTIVE COX-2 INHIBITORS - 5,6-DIARYLTHIAZOLO[3,2-B][1,2,4]TRIAZOLES

Authors
ROY P LEBLANC Y BALL RG BRIDEAU C CHAN CC CHAURET N CROMLISH W ETHIER D GAUTHIER JY GORDON R GREIG G GUAY J KARGMAN S LAU CK ONEILL G SILVA J THERIEN M VANSTADEN C WONG E XU L PRASIT P
Citation
P. Roy et al., A NEW SERIES OF SELECTIVE COX-2 INHIBITORS - 5,6-DIARYLTHIAZOLO[3,2-B][1,2,4]TRIAZOLES, Bioorganic & medicinal chemistry letters, 7(1), 1997, pp. 57-62
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
1
Year of publication
1997
Pages
57 - 62
Database
ISI
SICI code
0960-894X(1997)7:1<57:ANSOSC>2.0.ZU;2-A
Abstract
A series of 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles was prepared for evaluation of potency and selectivity against human COX-I and COX-2 e nzymes. This lead to the discovery of L-768,277, a potent and selectiv e COX-2 inhibitor that also demonstrated good in vivo activity. Copyri ght (C) 1996 Elsevier Science Ltd