BLOCKADE OF K-ATP CHANNELS WITH GLIBENCLAMIDE DOES NOT ABOLISH PRECONDITIONING DURING DEMAND ISCHEMIA

Authors
CORREA SD SCHAEFER S
Citation
Sd. Correa et S. Schaefer, BLOCKADE OF K-ATP CHANNELS WITH GLIBENCLAMIDE DOES NOT ABOLISH PRECONDITIONING DURING DEMAND ISCHEMIA, The American journal of cardiology, 79(1), 1997, pp. 75
Citations number
18
Categorie Soggetti
Cardiac & Cardiovascular System
Journal title
The American journal of cardiology → ACNP
ISSN journal
00029149
Volume
79
Issue
1
Year of publication
1997
Database
ISI
SICI code
0002-9149(1997)79:1<75:BOKCWG>2.0.ZU;2-N
Abstract
The role of adenosine triphosphate-sensitive potassium channels in the adaptive response to demand ischemia was tested in 22 patients treate d with placebo or glibenclamide before sequential exercise testing or atrial pacing, Glibenclamide did not affect the improvement in signs o f ischemia in both protocols, indicating that opening of these channel s is not a mechanism of this adaptive response in humans.