REPETITIVE EXPOSURE TO THE HOT-PLATE TEST PRODUCES STRESS-INDUCED ANALGESIA AND ALTERS BETA-ENDORPHIN NEURONAL TRANSMISSION WITHIN THE PERIAQUEDUCTAL GRAY OF THE RAT

Repetitive exposure of rats to a hot plate induced a novel non-opioid form of stress induced analgesia. The exposure caused a persistent 1.5 -2 s increase in tail flick latency which was not attenuated by system ic naltrexone, but was completely inhibited by systemic MK-801. Concom itantly, alterations occurred in the ability to pharmacologically dist inguish multiple beta-endorphin receptors in the periaqueductal gray. Thus, in response to different forms of stress, different pathways may be activated by beta-endorphin, resulting in stress induced analgesia s with varied pharmacological characteristics (e.g., opioid and non-op ioid).