REPETITIVE EXPOSURE TO THE HOT-PLATE TEST PRODUCES STRESS-INDUCED ANALGESIA AND ALTERS BETA-ENDORPHIN NEURONAL TRANSMISSION WITHIN THE PERIAQUEDUCTAL GRAY OF THE RAT

Citation
Aa. Hawranko et al., REPETITIVE EXPOSURE TO THE HOT-PLATE TEST PRODUCES STRESS-INDUCED ANALGESIA AND ALTERS BETA-ENDORPHIN NEURONAL TRANSMISSION WITHIN THE PERIAQUEDUCTAL GRAY OF THE RAT, Brain research, 667(2), 1994, pp. 283-286
Citations number
14
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
00068993
Volume
667
Issue
2
Year of publication
1994
Pages
283 - 286
Database
ISI
SICI code
0006-8993(1994)667:2<283:RETTHT>2.0.ZU;2-L
Abstract
Repetitive exposure of rats to a hot plate induced a novel non-opioid form of stress induced analgesia. The exposure caused a persistent 1.5 -2 s increase in tail flick latency which was not attenuated by system ic naltrexone, but was completely inhibited by systemic MK-801. Concom itantly, alterations occurred in the ability to pharmacologically dist inguish multiple beta-endorphin receptors in the periaqueductal gray. Thus, in response to different forms of stress, different pathways may be activated by beta-endorphin, resulting in stress induced analgesia s with varied pharmacological characteristics (e.g., opioid and non-op ioid).