FAILURE OF AMNIOTIC-FLUID CELL-GROWTH - IS IT RELATED TO FETAL ANEUPLOIDY

We investigated outcome in patients whose amniotic-fluid-cell samples showed unexplained growth failure in culture, 32 of 7872 amniocentesis samples were classified as unexplained growth failures. 10 women did not have repeat cytogenetic testing, but among their pregnancies there were 4 abnormal outcomes (1 fetal bladder-outlet obstruction, 2 still births, and 1 acardiac twin). Of the 2 2 patients who had repeat karyo typic analysis, 18 had normal fetal karyotypes, However, 4 fetuses wer e aneuploid (2 trisomy 21, 1 trisomy 13, and 1 Pallister-Killian syndr ome).