Rl. Sager et al., ANATOMOPATHOLOGIC LESIONS OF EXPERIMENTAL POLIOENCEPHALOMALACIA IN CALVES, Archivos de medicina veterinaria, 28(2), 1996, pp. 117-124
In this paper, anatomopathologic lesions of 12 calves with induced pol
ioencephalomalacia are described. Euthanasia was performed at differen
t stages of The disease which allowed us to recognize a lesion pattern
characterized by initial neuronal necrosis of the gray matter of the
cerebral cortex, followed by endothelial cell necrosis of the blood ca
pillaries. In this hiperacute stage, a few animals showed mild infiltr
ation with neutrophils. In a more advanced stage of the disease, regen
eration of the endothelial cells was prominent but with necrosis of th
e glial cells with infiltration of macrophages in the perivascular spa
ces. The latter condition was characterized by cavitation of the cereb
ral cortex. The use of UV light was useful to recognize different patt
erns of light was useful to recognize different patterns of autofluore
scence that help in the gross diagnosis of the disease. The hiperacute
presentation (sudden death with cerebral oedema) showed small fluores
cent areas, but those calves that carried the disease for 2-3 days sho
wed extensive autofluorescence areas. In the more advanced condition,
fluorescence almost disappeared as a consequence of the extensive cavi
tation of the cortex.