HUMAN P-GLYCOPROTEIN AS A MULTIDRUG TRANSPORTER ANALYZED BY USING TRANSEPITHELIAL TRANSPORT-SYSTEM

Authors
UEDA K SAEKI T HIRAI M TANIGAWARA Y TANAKA K OKAMURA M YASUHARA M HORI R INUI K KOMANO T
Citation
K. Ueda et al., HUMAN P-GLYCOPROTEIN AS A MULTIDRUG TRANSPORTER ANALYZED BY USING TRANSEPITHELIAL TRANSPORT-SYSTEM, Japanese Journal of Physiology, 44, 1994, pp. 67-71
Citations number
10
Categorie Soggetti
Physiology
Journal title
Japanese Journal of Physiology → ACNP
ISSN journal
0021521X
Volume
44
Year of publication
1994
Supplement
2
Pages
67 - 71
Database
ISI
SICI code
0021-521X(1994)44:<67:HPAAMT>2.0.ZU;2-7
Abstract
To analyze the mechanism of drug transport, mechanism of inhibitors, a nd physiological substrates of human P-glycoprotein, we established a transepithelial transport system by introducing MDR1 cDNA into LLC-PK1 , a pig kidney epithelial cell line. P-glycoprotein functions as a ste roid transporter as well as a drug transporter as physiological functi ons. P-glycoprotein also transports MDR modulators such as cyclosporin A, FK506, and calcium channel blockers.