CL- CHANNEL AS A CHOLINERGIC ACH RECEPTOR RESPONSIBLE FOR GENERATION OF INHIBITORY JUNCTION POTENTIAL IN APLYSIA BUCCAL MUSCLE-CELLS

Action potentials in Aplysia MA1 neurons are known to produce inhibito ry junction potentials (IJPs) in muscle cells in a specific portion (m m block) of the buccal musculature. These IJPs are reversibly blocked by curare (d-TC), suggesting that the transmitter is acetylcholine (AC h) and the receptor is a cholinergic ACh receptor. Muscle fibres were enzymatically dissociated from the mm portion, and whole cell patch cl amp was performed onto those fibres to study the ionic mechanism assoc iated with the ACh reception. The results revealed that the ACh recept or is associated with a Cl- channel.