AXIAL SKELETON HOMEOSIS AND FORELIMB MALFORMATIONS IN HOXD-11 MUTANT MICE

Authors
FAVIER B LEMEUR M CHAMBON P DOLLE P
Citation
B. Favier et al., AXIAL SKELETON HOMEOSIS AND FORELIMB MALFORMATIONS IN HOXD-11 MUTANT MICE, Proceedings of the National Academy of Sciences of the United Statesof America, 92(1), 1995, pp. 310-314
Citations number
18
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Proceedings of the National Academy of Sciences of the United Statesof America → ACNP
ISSN journal
00278424
Volume
92
Issue
1
Year of publication
1995
Pages
310 - 314
Database
ISI
SICI code
0027-8424(1995)92:1<310:ASHAFM>2.0.ZU;2-R
Abstract
The Hoxd-11 gene was disrupted by homologous recombination in embryoni c stem cells. We found that Hoxd-11(-/-) mutant mice are viable and di splay homeotic transformations of their sacral vertebrae, while their forelimbs present abnormalities of some metacarpals and of the first r ow of carpal bones. These results are discussed in the light of curren t models of tetrapod axial skeleton and limb patterning.