INHIBITION OF ARACHIDONIC-ACID CYCLOOXYGENASE AND LIPOXYGENASE ACTIVITIES OF LEUKOCYTES BY INDOMETHACIN AND COMPOUND BW755C

Authors
RANDALL RW EAKINS KE HIGGS GA SALMON JA TATESON JE
Citation
Rw. Randall et al., INHIBITION OF ARACHIDONIC-ACID CYCLOOXYGENASE AND LIPOXYGENASE ACTIVITIES OF LEUKOCYTES BY INDOMETHACIN AND COMPOUND BW755C, Agents and actions, 43(3-4), 1994, pp. 176-178
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Agents and actions → ACNP
ISSN journal
00654299
Volume
43
Issue
3-4
Year of publication
1994
Pages
176 - 178
Database
ISI
SICI code
0065-4299(1994)43:3-4<176:IOACAL>2.0.ZU;2-M
Abstract
Arachidonic acid is metabolized via two pathways in leukocytes: cyclo- oxygenase, leading to the stable prostaglandins, and lipoxygenase lead ing to hydroxyacids. Indomethacin inhibits the cyclo-oxygenase selecti vely, whereas compound BW755C -amino-1-(m-(trifluoromethyl)phenyl)-2-p yrazoline) inhibits both pathways equally. This offers a possible expl anation for the differing activities of these two compounds in inflamm atory models in vivo. The patterns of product inhibition by the two co mpounds support the suggestion that 11-HETE (hydroxy-eicosatetraenoic acid) and 15-HETE can arise by incomplete operation of the cyclo-oxyge nase pathway.