INDUCTION OF COLLAGENASE SYNTHESIS IN CHONDROCYTES BY A FACTOR SYNTHESIZED BY INFLAMED SYNOVIAL TISSUE

Authors
KERWAR SS RIDGE SC LANDES MJ NOLAN JC ORONSKY AL
Citation
Ss. Kerwar et al., INDUCTION OF COLLAGENASE SYNTHESIS IN CHONDROCYTES BY A FACTOR SYNTHESIZED BY INFLAMED SYNOVIAL TISSUE, Agents and actions, 43(3-4), 1994, pp. 206-210
Citations number
20
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Agents and actions → ACNP
ISSN journal
00654299
Volume
43
Issue
3-4
Year of publication
1994
Pages
206 - 210
Database
ISI
SICI code
0065-4299(1994)43:3-4<206:IOCSIC>2.0.ZU;2-B
Abstract
Rabbit inflamed synovial tissue grown in culture synthesizes a factor that induces collagenase synthesis in chondrocytes and in cartilage, S ynthesis of this factor by the synovial tissue is inhibited by cyclohe ximide but not by indomethacin. The factor has an apparent molecular w eight of 30,000, is stable to heat and to trypsin treatment but is ina ctivated by acid. Induction of collagenase synthesis in chondrocytes o ccurs after a lag period of 6 hours.