Citation
Da. Willoughby et al., CALCIUM PYROPHOSPHATE-INDUCED PLEURISY IN RATS - A NEW MODEL OF ACUTE-INFLAMMATION, Agents and actions, 43(3-4), 1994, pp. 221-224
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
ISSN journal
00654299
Volume
43
Issue
3-4
Year of publication
1994
Pages
221 - 224
Database
ISI
SICI code
0065-4299(1994)43:3-4<221:CPPIR->2.0.ZU;2-N
Abstract
A model is described of acute inflammation in the pleural cavity of ra
ts using calcium pyrophosphate as the irritant. This model would seem
to simulate the pseudogout syndrome. It has been shown to be acute in
onset, dominated by polymorphonuclear cells, complement independent. T
he advantage of the model is that volume of exudate, numbers and types
of cells may be quantitated. Prostaglandins and cyclic AMP have been
measured in the migrating cells. The significance of these findings ha
s been discussed.