This article summarizes the origins of informatics, which is based on
the science, engineering, and technology of computer hardware, softwar
e, and communications. In just four decades, from the 1950s to the 199
0s, computer technology has progressed from slow, first-generation vac
uum tubes, through the invention of the transistor and its incorporati
on into microprocessor chips, and ultimately, to fast, fourth-generati
on very-large-scale-integrated silicon chips. Programming has undergon
e a parallel transformation, from cumbersome, first-generation, machin
e languages to efficient, fourth-generation application-oriented langu
ages. Communication has evolved from simple copper wires to complex fi
beroptic cables in computer-linked networks. The digital computer has
profound implications for the development and practice of clinical med
icine.