Three patients with a papillary carcinoma arising in a thyroglossal du
ct cyst are presented and the literature is reviewed. This rare malign
ancy is seen mostly in women between the ages of 20 and 50 years. The
distribution of carcinoma subtypes differs from that of thyroid carcin
omas and thyroglossal duct carcinoma is recognized as a primary tumour
. The diagnosis is seldom made pre-operatively though especially in ol
der patients with midline swellings in the neck the diagnosis should b
e considered. Sistrunk's operation is the treatment of choice. In this
operation the cyst, the middle part of the hyoid bone and the thyrogl
ossal duct are removed in continuity.