POSITIVE INTERFERENCE OF MERTHIOLATE IN THE TDX DIGOXIN ASSAY IN CONTROL SAMPLES - USED IN THE BELGIAN EXTERNAL QUALITY ASSESSMENT (EQA) SCHEME

Authors
DEVLEESCHOUWER N LIBEER JC SCHIETTECATTE J MAES V DEMOLDER J DEBUSSCHERE PM GORUS F
Citation
N. Devleeschouwer et al., POSITIVE INTERFERENCE OF MERTHIOLATE IN THE TDX DIGOXIN ASSAY IN CONTROL SAMPLES - USED IN THE BELGIAN EXTERNAL QUALITY ASSESSMENT (EQA) SCHEME, European journal of clinical chemistry and clinical biochemistry, 32(12), 1994, pp. 935-937
Citations number
14
Categorie Soggetti
Biology,"Chemistry Medicinal
Journal title
European journal of clinical chemistry and clinical biochemistry → ACNP
ISSN journal
09394974
Volume
32
Issue
12
Year of publication
1994
Pages
935 - 937
Database
ISI
SICI code
0939-4974(1994)32:12<935:PIOMIT>2.0.ZU;2-4
Abstract
We investigated the possible origin of the spuriously high results obs erved with the Abbott TDx Immunoassay in the 1991 Belgian external qua lity assessment scheme for digoxin. The present work ascribes this dis crepancy to a matrix effect induced by the addition of merthiolate as preservative to the control samples. It consequently stresses the impo rtance of avoiding the use of this compound for preparing such samples .