NEW ANTIPROLIFERATIVE AND ANTIINFLAMMATORY 9,11-SECOSTEROLS FROM THE GORGONIAN PSEUDOPTEROGORGIA SP

Authors
HE HY KULANTHAIVEL P BAKER BJ KALTER K DARGES J COFIELD D WOLFF L ADAMS L
Citation
Hy. He et al., NEW ANTIPROLIFERATIVE AND ANTIINFLAMMATORY 9,11-SECOSTEROLS FROM THE GORGONIAN PSEUDOPTEROGORGIA SP, Tetrahedron, 51(1), 1995, pp. 51-58
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
51
Issue
1
Year of publication
1995
Pages
51 - 58
Database
ISI
SICI code
0040-4020(1995)51:1<51:NAAA9F>2.0.ZU;2-C
Abstract
Protein kinase C assay-guided study of the extracts of Pseudopterogorg ia sp. led to the isolation of three new 9,11-secosterols 1-3, in addi tion to a known secosterol 4. The latter was converted to semi-synthet ic sterols 6 and 7, and the structures of these were determined by the analysis of NMR and MS data. Secosterols 1-3, 6 and 7 exhibited moder ate inhibitory activity against protein kinase C, and 6 showed potent antiproliferative and antiinflammatory activity.