IDENTIFICATION OF INTERLEUKIN-6 (IL-6) EXPRESSING NEURONS IN THE CEREBELLUM AND HIPPOCAMPUS OF NORMAL ADULT-RATS

Authors
GADIENT RA OTTEN U
Citation
Ra. Gadient et U. Otten, IDENTIFICATION OF INTERLEUKIN-6 (IL-6) EXPRESSING NEURONS IN THE CEREBELLUM AND HIPPOCAMPUS OF NORMAL ADULT-RATS, Neuroscience letters, 182(2), 1994, pp. 243-246
Citations number
24
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
182
Issue
2
Year of publication
1994
Pages
243 - 246
Database
ISI
SICI code
0304-3940(1994)182:2<243:IOI(EN>2.0.ZU;2-8
Abstract
The cellular source of interleukin-6 (IL-6) in brain has not been iden tified. Using a sensitive, non-radioactive in situ hybridization techn ique, the cellular localization of IL-6 mRNA in different areas of the rat brain was analysed. Intense staining for IL-6 mRNA was found in P urkinje cells and hippocampal neurons. Our data support an essential r ole of IL-6 for cerebellar and hippocampal neuron differentiation and function.