AMPHETAMINE AND HALOPERIDOL MODULATORY EFFECTS ON PURKINJE-CELL ACTIVITY AND ON EEG POWER SPECTRA IN THE ACUTE RAT MODEL OF EPILEPSY

The modulation of cerebellar Purkinje cell activity and EEG from parie tal cortex was studied in the rat model of epilepsy induced by penicil lin under acute haloperidol and amphetamine treatment. The discharge p attern of Purkinje cells showed tendency towards inhibition and EEG po wer spectra increased after parenteral administration of penicillin (1 000000 IU/kg, i.p.). Acute haloperidol treatment (1 mg/kg, i.p.), perf ormed after the development of penicillin induced epileptic episodes, elicited a prominent excitation of Purkinje cell discharges associated with parallel increase in mean EEG power spectra. However, acute DL-a mphetamine treatment induced marked suppression of Purkinje cell disch arges as well as outstanding decrease of the mean EEG power spectra. T hese results indicate that cerebellar Purkinje cells may be important in the control of seizure activity and that noradrenergic influences a re relevant.