PRODUCTION OF INTERLEUKIN-3 BY MURINE CENTRAL-NERVOUS-SYSTEM NEURONS

Authors
KONISHI Y KAMEGAI M TAKAHASHI K KUNISHITA T TABIRA T
Citation
Y. Konishi et al., PRODUCTION OF INTERLEUKIN-3 BY MURINE CENTRAL-NERVOUS-SYSTEM NEURONS, Neuroscience letters, 182(2), 1994, pp. 271-274
Citations number
20
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
182
Issue
2
Year of publication
1994
Pages
271 - 274
Database
ISI
SICI code
0304-3940(1994)182:2<271:POIBMC>2.0.ZU;2-K
Abstract
We examined expression and production of interleukin-3 (IL-3) mRNA and IL-3 protein in mouse primary cultured neurons and glia by the revers e transcription and polymerase chain reaction and a bioassay using an IL-3-dependent cell line. IL-3 mRNA was demonstrated mainly in hippoca mpal neurons but not in glia, while a small but definite production of bioactive IL-3 was detected in septal and hippocampal neuronal cultur es. Thus, endogenous IL-3 might be produced by certain neurons in situ .