LOW POSITIVE PREDICTIVE VALUE OF ANTI-BRUGIA MALAYI IGG AND IGG(4) SEROLOGY FOR THE DIAGNOSIS OF WUCHERERIA-BANCROFTI

Authors
CHANTEAU S GLAZIOU P MOULIAPELAT JP PLICHART C LUQUIAUD P CARTEL JL
Citation
S. Chanteau et al., LOW POSITIVE PREDICTIVE VALUE OF ANTI-BRUGIA MALAYI IGG AND IGG(4) SEROLOGY FOR THE DIAGNOSIS OF WUCHERERIA-BANCROFTI, Transactions of the Royal Society of Tropical Medicine and Hygiene, 88(6), 1994, pp. 661-662
Citations number
8
Categorie Soggetti
Public, Environmental & Occupation Heath","Tropical Medicine
Journal title
Transactions of the Royal Society of Tropical Medicine and Hygiene → ACNP
ISSN journal
00359203
Volume
88
Issue
6
Year of publication
1994
Pages
661 - 662
Database
ISI
SICI code
0035-9203(1994)88:6<661:LPPVOA>2.0.ZU;2-5
Abstract
Enzyme-linked immunosorbent assays (ELISAs) for anti-Brugia malayi imm unoglobulin (Ig) G and IgG(4) were evaluated on sera from 1561 subject s in French Polynesia for the serodiagnosis of Wuchereria bancrofti fi lariasis, compared with the test for Onchocerca gibsoni circulating an tigen (Og4C3) as a 'gold standard'. The sensitivity of the ELISA-IgG a nd ELISA-IgG(4) assays was 90.8% and 94.5%, and the specificity was 45 .9% and 50.7%. The positive predictive values were 41% and 45% respect ively for an antigen prevalence rate of 30%. Thus antibody prevalences exceeded by two-fold the antigen prevalence, which itself exceeded by two-fold the prevalence of microfilaraemia.