LIVER LIPOXYGENASE ARACHIDONIC-ACID METABOLITES IN STREPTOZOTOCIN-INDUCED DIABETES IN RATS

Authors
ROSELLOCATAFAU J HOTTER G CLOSA D ORTIZ MA POUTORELLO JM GIMENO M BIOQUE G GELPI E
Citation
J. Rosellocatafau et al., LIVER LIPOXYGENASE ARACHIDONIC-ACID METABOLITES IN STREPTOZOTOCIN-INDUCED DIABETES IN RATS, Prostaglandins, leukotrienes and essential fatty acids, 51(6), 1994, pp. 411-413
Citations number
15
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Prostaglandins, leukotrienes and essential fatty acids → ACNP
ISSN journal
09523278
Volume
51
Issue
6
Year of publication
1994
Pages
411 - 413
Database
ISI
SICI code
0952-3278(1994)51:6<411:LLAMIS>2.0.ZU;2-G
Abstract
We have studied the liver 15-hydroxyeicosatetraenoic acid (15-HETE) an d leukotriene B-4 (LTB(4)) levels in streptozotocin- (ST)-induced diab etes in rats using liquid chromatography and radioimmunological techni ques. Diabetic rats showed significant alterations of liver lipoxygena se metabolites when compared to controls, These 15-HETE and LTB(4) inc reases were concomitant with raised levels of plasma and tissue thromb oxane B-2 (TXB(2)) and also urinary 2,3-dinor-TXB(2) in plasma and uri ne, respectively. These changes confirm an activation of 5- and 15-lip oxygenase in the liver 3 days after i.p. ST administration.