THE EFFECT OF CAFFEINE ON PROSTAGLANDIN OUTPUT FROM THE PERFUSED MESENTERIC VASCULAR BED OF THE RAT

Authors
NADERALI EK POYSER NL
Citation
Ek. Naderali et Nl. Poyser, THE EFFECT OF CAFFEINE ON PROSTAGLANDIN OUTPUT FROM THE PERFUSED MESENTERIC VASCULAR BED OF THE RAT, Prostaglandins, leukotrienes and essential fatty acids, 51(6), 1994, pp. 415-418
Citations number
10
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Prostaglandins, leukotrienes and essential fatty acids → ACNP
ISSN journal
09523278
Volume
51
Issue
6
Year of publication
1994
Pages
415 - 418
Database
ISI
SICI code
0952-3278(1994)51:6<415:TEOCOP>2.0.ZU;2-7
Abstract
Caffeine significantly (p < 0.05) increased the output of prostacyclin (PGI(2)) from the perfused rat mesenteric vascular bed. The outputs o f PGE(2) and PGF(2 alpha) were also increased by caffeine. This stimul atory response to caffeine did not show rapid desensitization. Ryanodi ne also increased PG output, suggesting that caffeine may be acting vi a the stimulation of a ryanodine receptor. The increased production of a vasodilator such as PGI(2) from blood vessels following exposure to caffeine may explain why caffeine has a beneficial effect in angina.