A COMPARATIVE REVIEW OF THE ADVERSE EFFECT PROFILES OF HEPARINS AND HEPARINOIDS

On the basis of the results of the 11 studies reviewed, thromboprophyl axis with unfractionated heparin, low molecular weight (LMW) heparin o r a heparinoid (danaparoid sodium; Org 10172) in patients undergoing t otal hip replacement did not show any important clinical differences w ith respect to the tolerability profiles of the different compounds. H owever, as a result of the great variability in the presentation and e valuation of blood losses and bleeding complications in these studies, it is mandatory to perform a direct comparison of the different compo unds in question in a double-blind, prospective clinical study.