REACTIVITY AND THE FATE OF SOME COMPOSITE BIOIMPLANTS BASED ON COLLAGEN IN CONNECTIVE-TISSUE

Three composite materials based on collagen gel prepared with ISC40 an d supplemented with the tripeptide glycine-histidine-lysine (GHK) mixe d with bioglass (BAS O), pure hydroxyapatite (grain: 0.5-1.0 mu m and 13-23 mu m) and shredded beef bone were tested in the laboratory rat a nd guinea-pig. In the course of 49 d, no signs of infectious inflammat ion or incompatibility were observed around subcutaneously installed b ioimplants. Particles of glass and hydroxyapatite became subject to ph agocytosis. Bone fragments were completely resorbed, and no signs of o steogenic activity were detected in the neighbourhood.