MUSCULAR COLOCYSTOPLASTY LINED WITH UROTHELIUM - EXPERIENCE WITH 16 PATIENTS

Objectives. Report of initial clinical experience with seromuscular co locystoplasty lined with urothelium (SCLU), a new operation to increas e bladder capacity and compliance without incorporating intestinal muc osa into the urinary tract. We have previously reported the technique and results of this procedure in a canine model. Methods. Sixteen pati ents underwent SCLU at two institutions. Their charts were reviewed re trospectively. The patients have been observed for a mean of 12 months . Results. Postoperatively, the bladder capacity increased an average of 2,4-fold from a mean of 139 mt (+/- 23.7 SEM) to 335 ml(+/- 38.9 SE M) in 14 patients (P < 0.001). Two patients required reaugmentation. P reoperative and postoperative bladder end filling pressures were avail able in 13 patients and decreased from a mean of 51.6 cm H2O (+/- 4.2 SEM) to 27.7 cm H2O (+/- 2.4 SEM) (P < 0.001). Of the 16 patients, 13 were incontinent preoperatively; 5 had renal insufficiency. Three pati ents have undergone renal transplantation following SCLU. After SCLU, 13 patients were dry day and night, 1 incontinent at night only, and 2 remained incontinent. Ten patients have undergone postoperative bladd er biopsy. Seven demonstrate urothelium covering the augmented portion of the bladder, 2 have regrowth of colonic mucosa, and 1 shows a mixt ure of colonic mucosa and urothelium. Conclusions. The results present ed suggest that SCLU is a viable alternative to the more conventional forms of bladder augmentation in selected patients.