With advances in the lateral approaches to the skull base and the incr
easing success of the management of jugular foramen lesions, a thoroug
h knowledge of the anatomy of this region is needed. The purpose of th
e present work is to study the detailed microsurgical anatomy of the l
ower skull base and the jugular foramen area as seen through the later
al approaches. Forty preserved skull base specimens and 5 fresh cadave
rs were dissected. The shape of the jugular bulb and its relationship
to nearby structures were recorded. The different venous connections o
f the bulb were noted. The hypoglossal canal was identified and its co
ntents were observed. The lower cranial nerves were studied at the lev
el of the upper neck, at their exit from the inferior skull base, and
in the jugular foramen. The results of the present study showed the co
mplex and variable anatomy of this area. The classic compartments of t
he jugular foramen were not always present. Cranial nerves IX through
XI followed different patterns while passing through the jugular foram
en, being separated from the jugular bulb by bone, thick fibrous tissu
e, or thin connective tissue.