EFFECTS OF ANTIOXIDANT THERAPY ON PERFUSI ON AND CONTRACTILITY OF LEFT-VENTRICULAR MYOCARDIUM IN PATIENTS WITH ALCOHOLIC INJURY OF THE HEART

Authors
ESCHANOVA FS GORGASLIDZE AG SMETNEV AS SERGIENKO VB
Citation
Fs. Eschanova et al., EFFECTS OF ANTIOXIDANT THERAPY ON PERFUSI ON AND CONTRACTILITY OF LEFT-VENTRICULAR MYOCARDIUM IN PATIENTS WITH ALCOHOLIC INJURY OF THE HEART, Kardiologia, 34(1-2), 1994, pp. 39-42
Citations number
18
Categorie Soggetti
Cardiac & Cardiovascular System
Journal title
Kardiologia → ACNP
ISSN journal
00229040
Volume
34
Issue
1-2
Year of publication
1994
Pages
39 - 42
Database
ISI
SICI code
0022-9040(1994)34:1-2<39:EOATOP>2.0.ZU;2-9
Abstract
Antioxidant Dibunol (20 mg/kg daily) was given for 20 days to 30 patie nts with alcoholic injury of the heart. Ten patients served as control s and received placebo for 20 days. Myocardial scintigraphy with thall ium 201 and radionuclide equilibrium ventriculography at rest and duri ng stress test were performed before and after Dibunol or placebo. Rel ative to baseline values Dibunol treated patients had increased left v entricular ejection fraction, maximal filling and ejection velocities, decreased enddiastolic and endsystolic volumes, increased myocardial TI 201 uptake and improved TI 201 washout. Therapy with Dibunol result ed in improvement of left ventricular perfusion and function.