EVALUATION OF CEREBRAL VASOREACTIVITY BY SPECT AND TRANSCRANIAL DOPPLER SONOGRAPHY USING THE ACETAZOLAMIDE TEST

rCBF SPECT with Tc-99m-HMPAO was performed prospectively in 29 patient s (3 controls and 26 stroke patients) as well as TCD studies in 20 pat ients (3 controls and 17 stroke patients) before and after 1 g i. v. a cetazolamide. The sensitivity of rCBF SPECT increased from 62% to 77% after acetazolamide provocation in stroke patients. In patients with a reversible neurological deficit, the sensitivity under resting condit ions was 50% which increased to 71%, while in cases with a permanent d eficit it increased from 75% to 83%. In the evaluation of the cerebrov ascular reserve capacity the results of rCBF SPECT and TCD coincided i n 91% of the hemispheres. The correlation was statistically significan t.