FR901451, A NOVEL INHIBITOR OF HUMAN-LEUKOCYTE ELASTASE FROM FLEXIBACTER SP .1. PRODUCING ORGANISM, FERMENTATION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES

Authors
FUJITA T HATANAKA H HAYASHI K SHIGEMATSU N TAKASE S OKAMOTO M OKUHARA M SHIMATANI K SATOH A
Citation
T. Fujita et al., FR901451, A NOVEL INHIBITOR OF HUMAN-LEUKOCYTE ELASTASE FROM FLEXIBACTER SP .1. PRODUCING ORGANISM, FERMENTATION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES, Journal of antibiotics, 47(12), 1994, pp. 1359-1364
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
47
Issue
12
Year of publication
1994
Pages
1359 - 1364
Database
ISI
SICI code
0021-8820(1994)47:12<1359:FANIOH>2.0.ZU;2-E
Abstract
A novel human leukocyte elastase (HLE) inhibitor, FR901451 was discove red in the fermentation broth of a bacteria. The bacteria was identifi ed as Flexibacter sp. No. 758. FR901451 has a molecular weight of 1269 and a molecular formula of C60H79N13O19. The mode of inhibition again st HLE is competitive, with a Ki value of 9.8 x 10(-9) M.