MATLYSTATINS, NEW INHIBITORS OF TYPE-IV COLLAGENASES FROM ACTINOMADURA-ATRAMENTARIA .3. STRUCTURE ELUCIDATION OF MATLYSTATIN-A TO MATLYSTATIN-F

Authors
HARUYAMA H OHKUMA Y NAGAKI H OGITA T TAMAKI K KINOSHITA T
Citation
H. Haruyama et al., MATLYSTATINS, NEW INHIBITORS OF TYPE-IV COLLAGENASES FROM ACTINOMADURA-ATRAMENTARIA .3. STRUCTURE ELUCIDATION OF MATLYSTATIN-A TO MATLYSTATIN-F, Journal of antibiotics, 47(12), 1994, pp. 1473-1480
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
47
Issue
12
Year of publication
1994
Pages
1473 - 1480
Database
ISI
SICI code
0021-8820(1994)47:12<1473:MNIOTC>2.0.ZU;2-1
Abstract
The structures of matlystatins, novel type IV collagenase inhibitors i solated from Actinomadur atramentaria, have been determined by a syste matic application of homo- and heteronuclear 2D NMR and FAB-MS/MS tech niques. Their structures were characterized by the presence of piperaz ic acid and hydroxamic acid moieties, structural motifs often seen in protease inhibitors.