AGONIST ACTIVATION OF 5-HT1A RECEPTORS IN THE MEDIAN RAPHE NUCLEUS AND FEMALE RAT LORDOSIS BEHAVIOR

Authors
UPHOUSE L MASWOOD S CALDAROLAPASTUSZKA M
Citation
L. Uphouse et al., AGONIST ACTIVATION OF 5-HT1A RECEPTORS IN THE MEDIAN RAPHE NUCLEUS AND FEMALE RAT LORDOSIS BEHAVIOR, Brain research, 668(1-2), 1994, pp. 271-275
Citations number
20
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
668
Issue
1-2
Year of publication
1994
Pages
271 - 275
Database
ISI
SICI code
0006-8993(1994)668:1-2<271:AAO5RI>2.0.ZU;2-8
Abstract
Proestrous rats were infused unilaterally into the median raphe nucleu s with 200-2,000 ng of the 5-HT1A agonist, 8-hydroxy-2-(di-n-propylami no)tetralin (8-OH-DPAT). Inhibition of the lordosis to mount ratio occ urred within 15 and 10 min, respectively, following infusion with 1,00 0 or 2,000 ng of the drug. Infusion of 2,000 ng of the 5-HT2 agonist, (+/-)-(2,5-dimethoxy-4-iodopbenyl)-2-aminopropane HCl (DOI), or 4,000 ng 5-HT (creatinine sulfate) failed to substantially reduce lordosis b ehavior.