A NEW TOOL FOR STUDYING PROTEIN-STRUCTURE AND FUNCTION

Authors
CORNISH VW SCHULTZ PG
Citation
Vw. Cornish et Pg. Schultz, A NEW TOOL FOR STUDYING PROTEIN-STRUCTURE AND FUNCTION, Current opinion in structural biology, 4(4), 1994, pp. 601-607
Citations number
69
Categorie Soggetti
Cell Biology",Biology
Journal title
Current opinion in structural biology → ACNP
ISSN journal
0959440X
Volume
4
Issue
4
Year of publication
1994
Pages
601 - 607
Database
ISI
SICI code
0959-440X(1994)4:4<601:ANTFSP>2.0.ZU;2-C
Abstract
A technique that allows for the site-specific incorporation of a large variety of unnatural amino acids into proteins has been developed. Th is methodology has been used to substitute amino acids with novel elec tronic, steric. and spectroscopic properties into proteins, providing new insights into the mechanisms of protein stability, enzymatic catal ysis and signal transduction.