PRESSURE-TUNING INFRARED AND SOLUTION RAMAN-SPECTROSCOPIC STUDIES OF 17-BETA-ESTRADIOL AND SEVERAL A-RING AND 17-ALPHA-ETHYNYLESTRADIOL DERIVATIVES

The vibrational spectrum of the hormonal steriod (17)beta-estradiol ha s been assigned with the aid of pressure-tuning infrared (IR) and solu tion Raman spectroscopy. In addition, a pressure-tuning IR study of 17 alpha-ethynylestradiol suggests that the 17 alpha-ethynyl hydrogen is hydrogen bonded in the solid state. Related work on a series of organ ometallic estradiol derivatives indicates that the effect of substitut ion chiefly affects the pressure sensitivities of vibrational modes lo cated near the point of substitution. For the alpha- and beta-[Cr(CO)( 3)]-17 beta-estradiol diastereomers, several vibrational spectroscopic differences were noted and the alpha-[Cr(CO)(3)] fragment apparently has a steric effect on the extent of hydrogen bonding.