NOVEL, EXTENDED TRANSITION-STATE MIMIC IN HIV-1 PROTEASE INHIBITORS WITH PERIPHERAL C-2-SYMMETRY

Authors
ETTMAYER P HUBNER M BILLICH A ROSENWIRTH B GSTACH H
Citation
P. Ettmayer et al., NOVEL, EXTENDED TRANSITION-STATE MIMIC IN HIV-1 PROTEASE INHIBITORS WITH PERIPHERAL C-2-SYMMETRY, Bioorganic & medicinal chemistry letters, 4(24), 1994, pp. 2851-2856
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
24
Year of publication
1994
Pages
2851 - 2856
Database
ISI
SICI code
0960-894X(1994)4:24<2851:NETMIH>2.0.ZU;2-O
Abstract
Extension of hydroxyethylene containing transition state mimics in HIV -protease inhibitors by carboxy or hydroxymethyl substituents led to p otent competitive enzyme inactivation as well as inhibition of HIV-1 r eplication in MT4-cells. Two diastereomeric series are discussed.