STRUCTURE-ACTIVITY OF TOPOISOMERASE-I POISONS RELATED TO HOECHST-33342

Authors
SUN Q GATTO B YU CA LIU A LIU LF LAVOIE EJ
Citation
Q. Sun et al., STRUCTURE-ACTIVITY OF TOPOISOMERASE-I POISONS RELATED TO HOECHST-33342, Bioorganic & medicinal chemistry letters, 4(24), 1994, pp. 2871-2876
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
24
Year of publication
1994
Pages
2871 - 2876
Database
ISI
SICI code
0960-894X(1994)4:24<2871:SOTPRT>2.0.ZU;2-3
Abstract
A series of bisbenzimidazoles related to Hoechst 33342 were synthesize d. Data on the relative activity of these bisbenzimidazoles as topoiso merase I poisons suggest that considerable flexibility exists in the l ocation of the tertiary alkylamine moiety. With the exception of aryla mine analogs, cytotoxicity was generally consistent with their relativ e potency as topoisomerase I poisons.