ENANTIOSELECTIVE HYDROLYSIS OF (+ -)-CHLORAMPHENICOL PALMITATE BY HYDROLASES/

Authors
CHENEVERT R POULIOT R BUREAU P
Citation
R. Chenevert et al., ENANTIOSELECTIVE HYDROLYSIS OF (+ -)-CHLORAMPHENICOL PALMITATE BY HYDROLASES/, Bioorganic & medicinal chemistry letters, 4(24), 1994, pp. 2941-2944
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
24
Year of publication
1994
Pages
2941 - 2944
Database
ISI
SICI code
0960-894X(1994)4:24<2941:EHO(-P>2.0.ZU;2-L
Abstract
(+/-)-Chloramphenicol palmitate has been efficiently resolved by enant ioselective hydrolysis in organic medium in the presence of Rhizopus s p. lipase affording the palmitate of RR-chloramphenicol and SS-chloram phenicol in high chemical and enantiomeric yields.