MECHANISTIC STUDIES OF AN ANTIBODY WITH CHORISMATE MUTASE ACTIVITY

Authors
SHIN JA HILVERT D
Citation
Ja. Shin et D. Hilvert, MECHANISTIC STUDIES OF AN ANTIBODY WITH CHORISMATE MUTASE ACTIVITY, Bioorganic & medicinal chemistry letters, 4(24), 1994, pp. 2945-2948
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
24
Year of publication
1994
Pages
2945 - 2948
Database
ISI
SICI code
0960-894X(1994)4:24<2945:MSOAAW>2.0.ZU;2-M
Abstract
Antibody 1F7 catalyzes the rearrangement of chorismate to prephenate. Its kinetic parameters are unaffected by changes in pH and display no solvent isotope effect or effects from addition of various cationic sa lts. These results are consistent with high-resolution structural info rmation of 1F7 bound to a transition state analog.