TH1 AND TH2 CD4(-CELLS IN THE PATHOGENESIS OF ORGAN-SPECIFIC AUTOIMMUNE-DISEASES() T)

CD4(+) T cells play a Key role in regulating immune system function. W hen these regulatory processes go awry, organ-specific autoimmune dise ases may develop. Here, Roland Liblau, Steven Singer and Hugh McDevitt explore the thesis that a particular subset of CD4(+) T cells, namely T helper 1 (Th1) cells, contributes to the pathogenesis of organ-spec ific autoimmune diseases, while another subset, Th2 cells, prevents th em.