A SIMPLE METHOD FOR ESTIMATING HALF-LIFE OF DRUGS OBEYING MICHAELIS-MENTEN ELIMINATION KINETICS

AIM: To establish a simple method for estimating half-life of drugs ob eying Michaelis Menten elimination kinetics. METHODS: A linear relatio nship is sketched between elimination half-life and drug concentration in blood that obey Michaelis-Menten elimination kinetics. A simple me thod is proposed to draw a regression line of blood drug concentration vs time after a single bolus intravenous injection. RESULTS & CONCLUS ION: The elimination, half-life can be read from the gression line. Th e method can also be used to estimate the time required for the plasma concentration of a drug to decrease any fraction.