Y. Ding et al., A SIMPLE METHOD FOR ESTIMATING HALF-LIFE OF DRUGS OBEYING MICHAELIS-MENTEN ELIMINATION KINETICS, Zhongguo yaoli xuebao, 16(1), 1995, pp. 65-67
AIM: To establish a simple method for estimating half-life of drugs ob
eying Michaelis Menten elimination kinetics. METHODS: A linear relatio
nship is sketched between elimination half-life and drug concentration
in blood that obey Michaelis-Menten elimination kinetics. A simple me
thod is proposed to draw a regression line of blood drug concentration
vs time after a single bolus intravenous injection. RESULTS & CONCLUS
ION: The elimination, half-life can be read from the gression line. Th
e method can also be used to estimate the time required for the plasma
concentration of a drug to decrease any fraction.