A SIMPLE METHOD FOR ESTIMATING HALF-LIFE OF DRUGS OBEYING MICHAELIS-MENTEN ELIMINATION KINETICS

Citation
Y. Ding et al., A SIMPLE METHOD FOR ESTIMATING HALF-LIFE OF DRUGS OBEYING MICHAELIS-MENTEN ELIMINATION KINETICS, Zhongguo yaoli xuebao, 16(1), 1995, pp. 65-67
Citations number
4
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
ISSN journal
02539756
Volume
16
Issue
1
Year of publication
1995
Pages
65 - 67
Database
ISI
SICI code
0253-9756(1995)16:1<65:ASMFEH>2.0.ZU;2-8
Abstract
AIM: To establish a simple method for estimating half-life of drugs ob eying Michaelis Menten elimination kinetics. METHODS: A linear relatio nship is sketched between elimination half-life and drug concentration in blood that obey Michaelis-Menten elimination kinetics. A simple me thod is proposed to draw a regression line of blood drug concentration vs time after a single bolus intravenous injection. RESULTS & CONCLUS ION: The elimination, half-life can be read from the gression line. Th e method can also be used to estimate the time required for the plasma concentration of a drug to decrease any fraction.