PHOTOCHEMICAL STUDIES .71. PHOTOSTABILITY STUDIES IN SOLID-STATE AND CRYSTAL-STRUCTURE OF MIFEPRISTONE

Authors
REISCH J ZAPPEL J RAO ARR HENKEL G
Citation
J. Reisch et al., PHOTOCHEMICAL STUDIES .71. PHOTOSTABILITY STUDIES IN SOLID-STATE AND CRYSTAL-STRUCTURE OF MIFEPRISTONE, Archiv der pharmazie, 327(12), 1994, pp. 809-811
Citations number
12
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Archiv der pharmazie → ACNP
ISSN journal
03656233
Volume
327
Issue
12
Year of publication
1994
Pages
809 - 811
Database
ISI
SICI code
0365-6233(1994)327:12<809:PS.PSI>2.0.ZU;2-3
Abstract
Mifepristone (1) was found to be stable against ultraviolet light unde r the usual storage conditions. Upon irradiation for two weeks it gave two photoproducts, characterized as (11 beta, 17 yl]-17-(1-propinyl)- 19-norandrosta-4,9-diene-3-one (2) and [5R,7 Xi, 8R,8aR]-5-[4-(dimethy lamino)phenyl]-4,5, 10-octahydro-7 methyl-8-(3-oxo-4-hexinyl)-2(3H)-ph enantrenone (3). Based on the crystal structure of 1 by X-ray diffract ion, the formation of 2 and 3 could be explained by the molecular pack ing in the crystal.