DOMAIN MOVEMENTS IN PROTEIN-KINASES

Authors
COX S RADZIOANDZELM E TAYLOR SS
Citation
S. Cox et al., DOMAIN MOVEMENTS IN PROTEIN-KINASES, Current opinion in structural biology, 4(6), 1994, pp. 893-901
Citations number
34
Categorie Soggetti
Cell Biology",Biology
Journal title
Current opinion in structural biology → ACNP
ISSN journal
0959440X
Volume
4
Issue
6
Year of publication
1994
Pages
893 - 901
Database
ISI
SICI code
0959-440X(1994)4:6<893:DMIP>2.0.ZU;2-Q
Abstract
Structural studies of the catalytic subunit of the cAMP-dependent prot ein kinase, both by crystallographic methods and in solution, reveal t wo conformations. Crystal structures of several other protein kinases have also been solved in the past year. With this combined information we can begin to define mobile domains and subdomains within the conse rved catalytic core.