TECHNIQUES FOR THE APPLICATION OF THE ANALYTICAL SOLUTION TO THE MULTICYLINDER SOMATIC SHUNT CABLE MODEL FOR PASSIVE NEURONS

The general solution for the voltage response to a generic impulse cur rent input in a multicylinder somatic shunt cable model for passive ne urones has been developed in [1]. In this paper we consider the applic ation of the multicylinder solution to examples previously considered by other authors for the single cylinder case: long and short current input and synaptic input modeled by an alpha-function and a multi-expo nential function. Simple expansions appropriate for small and large ti mes are found and efficient means of obtaining these expansions are cl early demonstrated. The dependence of the small and large time solutio ns upon the dimensionless parameters appearing in the conservation of current condition at the soma is investigated. Relevant limits of thes e dimensionless parameters which further simplify the small and large time solutions are related back to equivalent dimensional problems of interest to the practitioner. The well-posedness of the dimensionless inverse problem is investigated and a method proposed for the solution of the dimensional inverse problem for the somatic shunt.