ORAL-THERAPY OF NONINSULIN-DEPENDENT DIAB ETES-MELLITUS

The paper presents the results obtained in the treatment of 510 patien ts with noninsulin-dependent diabetes mellitus (NIDDM). Of them 420 re ceived bucarban, 30 gilemal and 60 adebit. Bucarban and gilemal decrea sed fasting glycemia and that after the standard meal. The patients we re also made less insulin-resistant. Hyperinsulinemia did not respond to the above drugs. Adebit demonstrated hypoglycemic, antihyperinsulin emic, antihyperbetalipoproteinemic and hypocholesterolemic activity. 1 0% of NIDDM patients developed primary resistance to oral sulfonamide drugs. In intact insulin secretion NIDDM patients were effectively tre ated both with sulfonamide sugar-reducing drugs and biguanid derivativ es.