Hospital cost-containment programs should themselves be cost-effective
, targeting high-cost physicians (which requires adjusting for case mi
x) and patients (which requires early identification). In this study,
clinical data available within 24 hours of admission from an electroni
c medical record system were used to develop statistical models to pre
dict hospital costs. In this retrospective analysis of clinical data a
nd diagnosis-related groups (DRGs), study subjects were 2,355 patients
admitted for at least 1 day to the medicine service at an urban teach
ing hospital with sophisticated electronic medical records. Of these 2
,355 patients, 1,663 (71%) had one of the 41 most common DRGs. Predict
ive models were derived on a random subset of two thirds of the patien
ts and were validated on the remaining third. The following patient da
ta were obtained: admission and prior diagnostic test results, diagnos
es, vital signs; demographic data; prior inpatient and outpatient visi
ts; tests and treatments ordered within 24 hours of admission (discret
ionary data); DRGs; and total inpatient costs (estimated from charges)
. Diagnosis-related groups explained 24% of the variance in total cost
s in the derivation patient set and 16% in the validation set. When on
ly nondiscretionary data were used, the models retained only clinical
laboratory results and prior diagnoses, explaining 20% of the derivati
on set variance in total costs and 16% in the validation set. Adding D
RGs increased the variance explained in the derivation set to 34%, but
decreased to 24% in the validation set. Adding discretionary data sub
stantially increased the explained variance in the derivation and vali
dation patient sets. The models' median predicted costs underestimated
true costs by 10% to 13%, with the lowest error in the models using a
ll types of variables. Clinical data gathered during routine clinical
care can be used to adjust for case mix and identify high-cost patient
s early in their hospital stays, when they could be targeted by cost-c
ontainment interventions.